Table 2.
Associations betweenNOXAandMCL1genotypes and SCCHN risk
| Gene Varianta |
Control |
Overall (n = 372) |
Oropharynx (n = 184) |
Non-oropharynx (n = 188) |
|||
|---|---|---|---|---|---|---|---|
| n = 315 (%) | Patients (%) | ORb (95%CI) | Patients (%) | ORb (95%CI) | Patients (%) | ORb (95%CI) | |
|
NOXA rs9957673 |
|
|
|
|
|
|
|
| CC |
216 (68.6) |
246 (66.1) |
1.0 |
118 (64.1) |
1.0 |
128 (68.1) |
1.0 |
| CT |
95 (30.2) |
115 (30.9) |
1.0 (0.7-1.4) |
60 (32.6) |
1.1 (0.7-1.7) |
55 (29.3) |
1.1 (0.9-1.6) |
| TT |
4 (1.3) |
11 (3.0) |
2.3 (0.7-7.4) |
6 (3.3) |
1.9 (0.4-8.1) |
5 (2.7) |
2.0 (0.5-8.3) |
| |
|
|
Ptrend =0.300 |
|
Ptrend = 0.180 |
|
Ptrend = 0.689 |
| CT + TT |
99 (31.4) |
126 (33.9) |
1.1 (0.8-1.5) |
66 (35.9) |
1.1 (0.7-1.7) |
60 (31.9) |
1.1 (0.7-1.6) |
|
NOXA rs4558496 |
|
|
|
|
|
|
|
| TT |
216 (68.6) |
253 (69.1) |
1.0 |
121 (65.8) |
1.0 |
136 (72.3) |
1.0 |
| TG |
85 (27.5) |
107 (29.3) |
1.0 (0.7-1.5) |
61 (33.2) |
1.23 (0.8-1.9) |
48 (25.5) |
0.9 (0.6-1.3) |
| GG |
14 (4.3) |
6 (1.6) |
0.4 (0.2-1.1) |
2 (1.1) |
0.34 (0.1-1.6) |
4 (2.1) |
0.4 (0.1-1.4) |
| |
|
|
Ptrend =0.411 |
|
Ptrend = 0.913 |
|
Ptrend = 0.224 |
| TG + GG |
99 (31.4) |
115 (30.9) |
1.0 (0.7-1.3) |
63 (34.3) |
1.1 (0.7-1.7) |
52 (27.7) |
0.8 (0.5-1.2) |
|
MCL1 rs9803935 |
|
|
|
|
|
|
|
| GG |
95 (30.2) |
127 (34.1) |
1.0 |
65 (35.3) |
1.0 |
62 (33.0) |
1.0 |
| GT |
157 (59.8) |
169 (45.4) |
0.8 (0.6-1.2) |
77 (41.9) |
0.8 (0.5-1.3) |
92 (48.9) |
0.9 (0.6-1.4) |
| TT |
63 (20.0) |
76 (20.4) |
0.9 (0.6-1.5) |
42 (22.8) |
1.1 (0.6-1.8) |
34 (18.1) |
0.9 (0.6-1.6) |
| |
|
|
Ptrend =0.516 |
|
Ptrend = 0.726 |
|
Ptrend = 0.463 |
| GG + GT |
252 (80.0) |
296 (79.6) |
1.0 |
142 (77.2) |
1.0 |
154 (81.9) |
1.0 |
| TT |
63 (20.0) |
76 (20.4) |
1.0 (0.7-1.5) |
42 (22.8) |
1.2 (0.7-1.9) |
34 (18.1) |
1.0 (0.6-1.6) |
|
MCL1 rs3738485 |
|
|
|
|
|
|
|
| GG |
93 (29.5) |
128 (34.4) |
1.0 |
65 (35.3) |
1.0 |
63 (33.5) |
1.0 |
| GC |
155 (49.2) |
168 (45.2) |
0.8 (0.6-1.2) |
77 (41.9) |
0.8 (0.5-1.3) |
91 (47.4) |
0.9 (0.6-1.3) |
| CC |
67 (21.3) |
76 (20.4) |
0.9 (0.6-1.3) |
42 (22.8) |
1.0 (0.6-1.7) |
34 (18.1) |
0.9 (0.5-1.5) |
| |
|
|
Ptrend =0.298 |
|
Ptrend = 0.528 |
|
Ptrend = 0.271 |
| GG + GC |
248 (78.7) |
296 (79.6) |
1.0 |
142 (77.2) |
1.0 |
154 (81.9) |
1.0 |
| CC | 67 (21.3) | 76 (20.4) | 1.0 (0.7-1.4) | 42 (22.8) | 1.1 (0.7-1.8) | 34 (18.1) | 0.9 (0.6-1.5) |
a The observed genotype frequencies among the controls were in agreement with Hardy-Weinberg equilibrium (P=0.069 for rs9957673, P=0.139 for rs4558496, P=0.898 for rs9803935, P=0.871 for rs3738485).
b ORs were adjusted for age, sex, smoking, drinking, and HPV16 serology.