Table 3.
Joint effects between HPV16 seropositivity andNOXA and MCL1genotypes on risk of SCCHN
| HPV16 Serology |
Gene Variant |
Control |
Overall (n = 372) |
Oropharynx (n = 184) |
non-oropharynx (n = 188) |
|||
|---|---|---|---|---|---|---|---|---|
| n = 315 (%) | Patients (%) | ORa (95%CI) | Patients (%) | ORa (95%CI) | Patients (%) | ORa (95%CI) | ||
| |
NOXA rs9957673 |
|
|
|
|
|
|
|
| - |
CC (Ref.) |
189 (60.0) |
187 (50.3) |
1.0 |
68 (37.4) |
1.0 |
119 (63.3) |
1.0 |
| - |
CT + TT |
85 (27.0) |
83 (22.3) |
1.0 (0.7-1.4) |
31 (17.0) |
1.0 (0.6-1.7) |
52 (27.7) |
1.0 (0.7-1.5) |
| + |
CC |
27 (8.6) |
59 (15.9) |
2.4 (1.4-4.0) |
50 (27.2) |
4.8 (2.8-8.3) |
9 (4.8) |
0.5 (0.2-1.2) |
| + |
CT + TT |
14 (4.4) |
43 (11.6) |
3.6 (1.9-6.8) |
35 (19.0) |
7.1 (3.6-14.3) |
8 (4.3) |
1.1 (0.4-2.8) |
| |
|
|
|
Ptrend =0.017 |
|
Ptrend < 0.001 |
|
Ptrend = 0.744 |
| |
NOXA rs4558496 |
|
|
|
|
|
|
|
| - |
TT (Ref.) |
188 (59.7) |
188 (50.8) |
1.0 |
66 (36.3) |
1.0 |
123 (65.4) |
1.0 |
| - |
TG + GG |
86 (27.3) |
86 (21.8) |
0.9 (0.6-1.4) |
33 (17.9) |
1.1 (0.7-1.8) |
48 (25.5) |
0.8 (0.5-1.3) |
| + |
TT |
28 (8.9) |
68 (18.3) |
2.7 (1.7-4.5) |
55 (29.9) |
5.6 (3.2-9.6) |
13 (6.9) |
0.8 (0.4-1.7) |
| + |
TG + GG |
13 (4.1) |
34 (9.1) |
2.8 (1.4-5.5) |
30 (16.3) |
6.1 (3.0-12.6) |
4 (2.1) |
0.4 (0.1-1.4) |
| |
|
|
|
Ptrend =0.086 |
|
Ptrend < 0.001 |
|
Ptrend = 0.197 |
| |
MCL1 rs9803935 |
|
|
|
|
|
|
|
| - |
GG + GT (Ref.) |
215 (68.2) |
224 (60.2) |
1.0 |
81 (44.0) |
1.0 |
143 (76.1) |
1.0 |
| - |
TT |
59 (18.7) |
46 (12.4) |
0.8 (0.5-1.2) |
18 (9.8) |
0.8 (0.5-1.5) |
28 (14.9) |
0.8 (0.5-1.3) |
| + |
GG + GT |
37 (11.8) |
72 (19.4) |
2.1 (1.3-3.3) |
61 (33.2) |
4.3 (2.6-7.1) |
11 (5.9) |
0.5 (0.2-1.0) |
| + |
TT |
4 (1.3) |
30 (8.1) |
8.1 (2.8-23.7) |
24 (13.0) |
14.9 (5.0-44.6) |
6 (3.2) |
2.7 (0.7-9.8) |
| |
|
|
|
Ptrend =0.030 |
|
Ptrend < 0.001 |
|
Ptrend = 0.317 |
| |
MCL1 rs3738485 |
|
|
|
|
|
|
|
| - |
GG + GC (Ref.) |
212 (67.3) |
223 (60.0) |
1.0 |
81 (44.0) |
1.0 |
142 (75.5) |
1.0 |
| - |
CC |
62 (19.7) |
47 (12.6) |
0.8 (0.5-1.2) |
18 (9.8) |
0.8 (0.4-1.4) |
29 (15.4) |
0.8 (0.5-1.3) |
| + |
GG + GC |
36 (11.4) |
73 (19.6) |
2.2 (1.4-3.4) |
61 (33.2) |
4.4 (2.7-7.2) |
12 (6.4) |
0.5 (0.3-1.1) |
| + |
CC |
5 (1.6) |
29 (7.8) |
6.3 (2.4-16.7) |
24 (13.0) |
11.7 (4.3-32.0) |
5 (2.7) |
1.9 (0.5-6.8) |
| Ptrend =0.071 | Ptrend < 0.001 | Ptrend = 0.189 | ||||||
a ORs were adjusted for age, sex, and tobacco smoking and alcohol drinking.