Table 4.
Joint effect between HPV16 seropositivity andNOXAandMCL1genotypes on risk of oropharyngeal cancer stratified by smoking status
| HPV16 Serology | Genotypes |
Never smokers |
Ever smokers |
Adjusted OR (95% CI) a |
|||
|---|---|---|---|---|---|---|---|
| Patients (n = 61) | Controls (n = 90) | Patients (n = 123) | Controls (n = 225) | Never smokers | Ever smokers | ||
| |
NOXA rs9957673 |
|
|
|
|
|
|
| - |
CC (Ref.) |
19 |
52 |
49 |
137 |
1.0 |
1.0 |
| - |
CT + TT |
7 |
30 |
24 |
55 |
0.7 (0.2-1.8) |
1.2 (0.7-2.2) |
| + |
CC |
18 |
7 |
32 |
20 |
8.3 (2.8-24.9) |
4.3 (2.4-8.4) |
| + |
CT + TT |
17 |
1 |
18 |
13 |
50.6 (6.1-422.0) |
4.1 (1.9-9.2) |
| |
|
|
|
|
|
Ptrend = 0.001 |
Ptrend = 0.004 |
| |
NOXA rs4558496 |
|
|
|
|
|
|
|
- |
TT (Ref.) |
19 |
57 |
47 |
131 |
1.0 |
1.0 |
|
- |
TG + GG |
7 |
25 |
26 |
61 |
0.7 (0.2-2.0) |
1.2 (0.7-2.1) |
| + |
TT |
26 |
7 |
29 |
21 |
13.4 (4.7-37.8) |
4.0 (2.0-7.7) |
| + |
TG + GG |
9 |
1 |
21 |
12 |
21.9 (2.5-192.6) |
4.7 (2.1-10.5) |
| |
|
|
|
|
|
Ptrend = 0.008 |
Ptrend = 0.002 |
| |
MCL1 rs3738485 |
|
|
|
|
|
|
| - |
GG + GT (Ref.) |
20 |
66 |
61 |
149 |
1.0 |
1.0 |
| - |
TT |
6 |
16 |
12 |
43 |
1.4 (0.5-4.3) |
0.7 (0.3-1.4) |
| + |
GG + GT |
27 |
7 |
34 |
30 |
15.4 (5.5-43.6) |
2.8 (1.6-5.1) |
| + |
TT |
8 |
1 |
16 |
3 |
28.0 (3.2-246.6) |
12.1 (3.4-43.3) |
| |
|
|
|
|
|
Ptrend < 0.001 |
Ptrend = 0.003 |
| |
MCL1 rs3738485 |
|
|
|
|
|
|
|
- |
GG + GC (Ref.) |
20 |
65 |
61 |
147 |
1.0 |
1.0 |
|
- |
CC |
6 |
17 |
12 |
45 |
1.3 (0.4-4.1) |
0.6 (0.3-1.3) |
| + |
GG + GC |
27 |
7 |
34 |
29 |
15.3 (5.4-43.5) |
2.9 (1.6-5.2) |
| + |
CC |
8 |
1 |
16 |
4 |
27.7 (3.1-244.7) |
8.8 (2.8-27.8) |
| Ptrend < 0.001 | Ptrend = 0.008 | ||||||
a ORs were adjusted for age, sex, and alcohol drinking.