Table 5.
Joint effect between HPV16 seropositivity andNOXAandMCL1genotypes on risk of oropharyngeal cancer stratified by drinking status
| HPV16 Serology | Genotypes |
Never drinkers |
Ever drinkers |
Adjusted OR (95% CI) a |
|||
|---|---|---|---|---|---|---|---|
| Patients (n = 36) | Controls (n = 90) | Patients (n = 148) | Controls (n = 225) | Never drinkers | Ever drinkers | ||
| |
NOXA rs9957673 |
|
|
|
|
|
|
| - |
CC (Ref.) |
14 |
57 |
54 |
132 |
1.0 |
1.0 |
| - |
CT + TT |
3 |
24 |
28 |
61 |
0.5 (0.1-1.8) |
1.2 (0.7-2.0) |
| + |
CC |
9 |
5 |
41 |
22 |
8.1 (2.2-29.5) |
4.3 (2.3-8.0) |
| + |
CT + TT |
10 |
4 |
25 |
10 |
12.7 (3.2-50.0) |
5.9 (2.6-13.3) |
| |
|
|
|
|
|
Ptrend = 0.015 |
Ptrend = 0.001 |
| |
NOXA rs4558496 |
|
|
|
|
|
|
|
- |
TT (Ref.) |
9 |
56 |
57 |
132 |
1.0 |
1.0 |
|
- |
TG + GG |
8 |
25 |
25 |
61 |
1.8 (0.6-5.4) |
1.0 (0.6-1.7) |
| + |
TT |
16 |
7 |
39 |
21 |
15.4 (4.8-49.2) |
4.1 (2.2-7.7) |
| + |
TG + GG |
3 |
2 |
27 |
11 |
12.9 (1.7-99.5) |
5.4 (2.5-11.6) |
| |
|
|
|
|
|
Ptrend = 0.019 |
Ptrend = 0.001 |
| |
MCL1 rs9803935 |
|
|
|
|
|
|
| - |
GG + GT (Ref.) |
12 |
65 |
69 |
150 |
1.0 |
1.0 |
| - |
TT |
5 |
16 |
13 |
43 |
1.8 (0.5-5.8) |
0.7 (0.3-1.4) |
| + |
GG + GT |
16 |
9 |
45 |
28 |
11.7 (3.9-34.7) |
3.3 (1.9-5.8) |
| + |
TT |
3 |
NA |
21 |
4 |
NA |
10.8 (3.5-33.0) |
| |
|
|
|
|
|
Ptrend = 0.002 |
Ptrend = 0.001 |
| |
MCL1 rs3738485 |
|
|
|
|
|
|
|
- |
GG + GC (Ref.) |
12 |
63 |
69 |
149 |
1.0 |
1.0 |
|
- |
CC |
5 |
18 |
13 |
44 |
1.6 (0.5-5.1) |
0.7 (0.3-1.3) |
| + |
GG + GC |
16 |
9 |
45 |
27 |
11.4 (3.8-34.1) |
3.4 (1.9-6.0) |
| + |
CC |
3 |
NA |
21 |
5 |
NA |
8.6 (3.1-23.9) |
| Ptrend = 0.760 | Ptrend = 0.001 | ||||||
a ORs were adjusted for age, sex, and tobacco smoking.