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. 2012 May 1;12:159. doi: 10.1186/1471-2407-12-159

Table 6.

Joint effect between HPV16 seropositivity andNOXAandMCL1genotypes on risk of oropharyngeal cancer stratified by age

HPV16 Serology Genotypes Age ≤ 58
 Age > 58
 Adjusted OR (95% CI) a
Patients (n = 116) Controls (n = 145) Patients (n = 68) Controls (n = 170) Age ≤ 58 Age > 58
 
 NOXA rs9957673
  
  
  
  
  
  
-
 CC (Ref.)
 39
 89
 29
 100
 1.0
 1.0
-
 CT + TT
 15
 38
 16
 47
 0.9 (0.5-2.0)
 1.2 (0.6-2.5)
+
 CC
 36
 14
 14
 13
 6.4 (3.0-13.6)
 4.0 (1.7-9.8)
+
 CT + TT
 26
 4
 9
 10
 14.9 (4.7-46.6)
 3.6 (1.3-10.0)
 
  
  
  
  
  
 Ptrend < 0.001
 Ptrend = 0.077
 
 NOXA rs4558496
  
  
  
  
  
  
-
 TT (Ref.)
 36
 90
 30
 98
 1.0
 1.0
-
 TG + GG
 18
 37
 15
 49
 1.2 (0.6-2.4)
 1.0 (0.5-2.1)
+
 TT
 38
 11
 17
 17
 9.5 (4.2-21.2)
 3.5 (1.6-7.9)
+
 TG + GG
 24
 7
 6
 6
 8.2 (3.2-21.3)
 3.9 (1.1-13.8)
 
  
  
  
  
  
 Ptrend < 0.001
 Ptrend = 0.222
 
 MCL1 rs9803935
  
  
  
  
  
  
-
 GG + GT (Ref.)
 44
 102
 37
 113
 1.0
 1.0
-
 TT
 10
 25
 8
 34
 0.9 (0.4-2.0)
 0.8 (0.3-1.8)
+
 GG + GT
 42
 17
 19
 20
 5.9 (3.0 -11.8)
 3.3 (1.6-8.0)
+
 TT
 20
 1
 4
 3
 47.2 (6.1 -368.2)
 3.9 (0.8-19.0)
 
  
  
  
  
  
 Ptrend < 0.001
 Ptrend = 0.338
 
 MCL1 rs3738485
  
  
  
  
  
  
-
 GG + GC (Ref.)
 44
 100
 37
 112
 1.0
 1.0
-
 CC
 10
 27
 8
 35
 0.8 (0.4-1.9)
 0.7 (0.3-1.7)
+
 GG + GC
 42
 16
 19
 20
 6.2 (3.1-12.5)
 3.3 (1.5-7.0)
+
 CC
 20
 2
 4
 3
 22.7 (5.0-103.5)
 3.8 (0.8-18.7)
            Ptrend < 0.001 Ptrend = 0.270

a ORs were adjusted for age, sex, tobacco smoking and alcohol drinking.