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During colonization of the colorectum, a transient inner submucosal plexus is present at the migrating wavefront at E7 (HH30; A) and E8 (HH32; B, arrowheads). The ENCCs in this inner plexus remain undifferentiated (p75+/Hu-) (C). By E10 (D), the inner plexus is no longer present and only the normal submucosal plexus is seen. ep, epithelium; mp, myenteric plexus; NoR, nerve of Remak
