Table 1.
Components of P-bodies and stress granules
| Name | Function | References |
|---|---|---|
| Components found predominantly in P-bodies | ||
| Ccr4/Pop2/Not complex | Deadenylase | Sheth and Parker 2003; Cougot et al. 2004 |
| Dcp1 | Decapping enzyme subunit | Sheth and Parker 2003; Cougot et al. 2004 |
| Dcp2 | Decapping enzyme | Sheth and Parker 2003; Cougot et al. 2004 |
| Edc1 and 2 | Decapping activators | Neef and Thiele 2009 |
| Edc3 | Decapping activator | Kshirsagar and Parker 2004; Fenger-Gron et al. 2005 |
| eIF4E-T | Translation repressor | Andrei et al. 2005; Ferraiuolo et al. 2005 |
| eRF1 and eRF3 | Translation termination | Buchan et al. 2008 |
| GW182 | miRNA function | Eystathioy et al. 2003 |
| Hedls/Ge-1 | Decapping activator | Fenger-Gron et al. 2005; Yu et al. 2005 |
| Lsm1-7 complex | Decapping activator | Ingelfinger et al. 2002; Sheth and Parker 2003 |
| Pat1/PatL1 | Translation repressor/decapping activator | Sheth and Parker 2003; Scheller et al. 2007 |
| Upf1-3 | Nonsense-mediated decay | Sheth and Parker 2006; Durand et al. 2007 |
| Components found predominantly in stress granules | ||
| 40S ribosomal subunit | Translation | Kedersha et al. 2002; Grousl et al. 2009 |
| Ataxin-2/Pbp1 | Translation/mRNA processing | Nonhoff et al. 2007; Buchan et al. 2008 |
| DDX3/Ded1 | RNA helicase | Chalupnikova et al. 2008; Lai et al. 2008; Hilliker et al. 2011 |
| eIF2α | Translation initiation | Kedersha et al. 2002; Kimball et al. 2003 |
| eIF3 | Translation initiation | Kedersha et al. 2002; Grousl et al. 2009 |
| eIF4A | Translation initiation | Low et al. 2005; Buchan et al. 2011 |
| eIF4B | Translation initiation | Low et al. 2005; Buchan et al. 2011 |
| eIF4G | Translation initiation | Kedersha et al. 2005; Hoyle et al. 2007 |
| FMRP | Translation, repression/miRNA function | Mazroui et al. 2002; Kim et al. 2006 |
| G3BP | Scaffolding protein, endoribonuclease | Tourriere et al. 2001 |
| Pabp | polyA-binding protein | Kedersha et al. 1999; Hoyle et al. 2007 |
| RACK1 | Signaling scaffold protein | Arimoto et al. 2008 |
| TIA-1/TIAR/Pub1/Ngr1 | Translation repression/mRNA stability | Kedersha et al. 1999; Buchan et al. 2008 |
| Components found in both P-bodies and stress granules | ||
| Agonaute proteins | miRNA function | Sen and Blau 2005; Leung et al. 2006 |
| Dhh1/Rck/p54/ | Translation repressor/decapping activator | Sheth and Parker 2003; Wilczynska et al. 2005 |
| eIF4E | Translation initiation | Andrei et al. 2005; Ferraiuolo et al. 2005; Hoyle et al. 2007 |
| FAST | Fas activated serine/ threonine phosphoprotein | Kedersha et al. 2005 |
| Rap55/Scd6 | Translation repressor | Yang et al. 2006; Teixeira and Parker 2007 |
| Xrn1 | 5′ to 3′ exonuclease | Sheth and Parker 2003; Kedersha et al. 2005 |