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King's college criteria.
| ACETAMINOPHEN-INDUCED ALF |
| Arterial pH <7.3 (regardless of HE) |
| OR all 3 of the following |
| – INR >6.5 |
| – Creatinine >300 μmol/l |
| – HE grade 3–4 |
| NON-ACETAMINOPHEN-INDUCED ALF |
| INR >6.5 (regardless of HE) |
| OR 3 of 5 of the following (regardless of HE) |
| – Age <10 or >40 years |
| – Etiology: indeterminate, drug-induced |
| – Time interval icterus to encephalopathy > 7 days |
| – INR >3.5 |
| – Bilirubin >300 μmol/l |
