Blood pressure and arterial baroreflex gain in normal salt (0.4% Na+) fed animals. Mean arterial pressure (MAP) for 12-h light (L)–dark (D) cycles for each of 5 days and the average of 5 days are shown in panels A and B, respectively in wildtype (+/+, n = 8) and homozygous βENaC mutant mice (m/m, n = 7). (C) Arterial baroreflex gain is significantly lower in βENaC m/m mice (n = 4) vs. +/+ controls. (D) Mean arterial blood pressure (MAP) variability during the last 24 h of blood pressure recording was significantly elevated in βENaC m/m mice (same animals as shown in A and B). (Figure reproduced from American Journal of Physiology, Renal Physiology 301; F443–F449, 2011, Figures 2, 3). Data are mean ± SEM. BPM is heart rate in beats per minute. *Significantly different from wildtype (+/+) control animals, p < 0.05.