Table 1.

Revised Bethesda Guidelines (BGrev); just one of these criteria needed to be met (3)

B1 Individuals diagnosed with colorectal cancer before the age of 50 y

B2 Synchronous or metachronous colorectal or other HNPCC*-related tumors (which include stomach, bladder, ureter, renal pelvis, biliary tract, brain (glioblastoma), sebaceous gland adenomas, keratoacanthomas and carcinoma of the small bowel), regardless of age

B3 Colorectal cancer with a high-microsatellite instability morphology† that was diagnosed before the age of 60 y

B4 Colorectal cancer with one or more first-degree relatives with colorectal cancer or other HNPCC-related tumors. One of the cancers must have been diagnosed before the age of 50 y (this includes adenoma, which must have been diagnosed before the age of 40 y)

B5 Colorectal cancer with two or more relatives with colorectal cancer or other HNPCC-related tumors, regardless of age

*HNPCC – hereditary nonpolyposis colorectal cancer.

†Presence of tumor infiltrating lymphocytes, Crohn's-like lymphocytic reaction, mucinous/signet ring differentiation, or medullary growth pattern.