Table 6.
Sensitivity, specificity, positive and negative predictive value of histological and clinical features in predicting microsatellite instability (MSI)
| Variable | Sensitivity | Specificity | Positive predictive value | Negative predictive value |
|---|---|---|---|---|
|
B3 criterion |
0.44 |
0.91 |
0.13 |
0.87 |
|
MSI histology |
0.79 |
0.85 |
0.20 |
0.80 |
|
MsPath score* |
0.86 |
0.85 |
0.18 |
0.82 |
|
Tumor infiltrating lymphocytes |
0.52 |
0.65 |
0.37 |
0.63 |
|
Any mucinous differentiation |
0.63 |
0.69 |
0.34 |
0.65 |
|
Poor differentiation |
0.27 |
0.89 |
0.13 |
0.88 |
|
Family history of cancers (B4.B5) |
0.64 |
0.92 |
0.13 |
0.87 |
|
Revised Bethesda guidelines |
0.78 |
0.77 |
0.3 |
0.7 |
| Revised Bethesda guidelines (modified B1, age limit <45 y) | 0.78 | 0.89 | 0.19 | 0.80 |
*Cut-off value = 1.