. Author manuscript; available in PMC: 2012 Aug 28.

Published in final edited form as: Curr Opin Pharmacol. 2003 Aug;3(4):443–448. doi: 10.1016/s1471-4892(03)00069-9

Table 1.

Contrasting effects of blocking chemokine receptors or their ligands during allergic airway inflammation.

Receptor	Knockout	Ligand	Blocking antibodies
CCR3	Decreased eosinophils, increased AHR [18^••]	CCL11	Decreased eosinophils [4,7,8]
			Reduced Th2 recruitment [6]
CCR4	No protection [22]	CCL22	Decreased eosinophils and AHR [20]
	Reduced AHR [23^•]	CCL17	Reduced Th2 recruitment [6]
			Decreased eosinophils and AHR [21]
CCR8	Decreased eosinophils [25^••]	CCL1	Decreased eosinophils [24^••]
	No protection [24^••,26^••]		No effect [24^••]