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. Author manuscript; available in PMC: 2012 Aug 28.
Published in final edited form as: Endocrinology. 2011 Oct 11;152(12):5029–5040. doi: 10.1210/en.2011-1124

Figure 7. LPS induces IL-6 accumulation and expansion in in vitro matured COCs.

Figure 7

(A) IL-6 accumulation in cell-free supernatants was measured from groups of 10 – 20 COCs treated with 0, 0.1, 1 or 10 μg/ml LPS in the presence of 2.5 μg/ml FSH. IL-6 concentrations are presented as mean pg/ml/COC + SEM from a total of 216 across 4 independent experiments. * P < 0.05 compared to untreated controls; analysis by ANOVA followed by Dunnett’s post-hoc test. (B) COC expansion rates were recorded from groups of 10 – 20 COCs,, following treatment with 0, 0.1, 1 or 10 μg/ml LPS in the absence (□) or presence (■) of 2.5 μg/ml FSH. COC expansion data are presented as percentages from a total of 422 COCs across 8 independent experiment. * P < 0.05 compared to untreated COCs within FSH treatment group using a χ2 test.