TABLE 1.
General and Psychiatric Characteristics, Duplication Details, and 15q11-q13 Duplication syndrome Features in Identified Carriers
| General Features |
|||||
|---|---|---|---|---|---|
| Participant | Sex | Diagnosis | Age at Onset (years) |
Family History |
|
| Psychopathology | Duplication Status |
||||
| Case patient 1 (Danish) | Male | Schizophrenia | 10 | Three brothers with schizophrenia; mother with unknown mental illness | Unknown in all four |
| Case patient 2 (German) | Male | Schizophrenia | 18 | One brother with depressive mood | Unknown |
| Case patient 3 (United Kingdom) | Female | Schizoaffective disorder | 41 | One daughter with autism, intellectual disability, and schizophrenia | Unknown |
| Case patient 4 (United Kingdom) | Male | Schizophrenia | 16 | Mother with schizophrenia and low IQ; one brother with possible schizophrenia and low IQ | Unknown in both |
| Case patient 5 (Icelandic) | Female | Schizophrenia | 21 | Mother with bipolar disorder | Yes |
| Case patient 6 (Icelandic) | Female | Bipolar disorder | 13 | One brother with bipolar disorder; mother with recurrent depression | No for brother; unknown for mother |
| Case patient 7 (Icelandic) | Female | Autism | 1 | One sister with idiopathic seizures and attention deficit hyperactivity disorder | No |
| Comparison subject 1 (Icelandic) | Female | No known diagnosis | Unknown | ||
| Comparison subject 2 (Icelandic) | Female | Preeclampsia | Unknown | ||
| Comparison subject 3 (Icelandic) | Female | Alzheimer’s disease | Unknown | ||
| Comparison subject 4 (Icelandic) | Female | No known diagnosis | Unknown | ||
| Comparison subject 5 (Icelandic) | Female | No known diagnosis | Unknown | ||
a
Other known features, including seizures and hypotonia, were not reported for any of the case patients and were unknown for comparison subjects.
b
Not reported.