a) Locomotor activity in Eps15
-/- mice. Activity was recorded during a period of 10 minutes in an open field arena. N = 7 for Eps15
-/- male mice and n= 16 for matched control wildtype.
b) Schematic representation of the Trim6-Trim30 genes cluster on chromosome 7. Boxes represent the sequential positions of the Trim6, Trim34, Trim5/12 and Trim30 genes. Trim5 and Trim12a genes are only present in the C57BL/6J genome occurred by segmental duplication of the Trim12c gene present in all 17 strains. The flanking Trim34 and Trim30 genes do not vary between strains. Coordinates are given for Build37 of the mouse genome.