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. 2012 Aug 27;209(9):1529–1535. doi: 10.1084/jem.20112646

Figure 2.

Figure 2.

TGF-β–dependent in vitro conversion of naive T cells into T reg cells. (A) Frequencies of Foxp3-expressing cells among CD4+ T cells in 2.5-d cultures containing the indicated concentrations of TGF-β have been measured. (B) Conversion rate of foxp3CNS1mut T cells normalized on conversion rate of foxp3WT T cells at the indicated TGF-β concentrations. Data are representative of two (0.05 and 2 ng/ml TGF-β) or three (0, 0.1, 0.5, and 1 ng/ml TGF-β) independent experiments. Error bars indicate means ± SEM. ***, P < 0.001; **, P < 0.01.