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. 2012 Aug 27;209(9):1611–1627. doi: 10.1084/jem.20111580

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© 2012 Reis et al.

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Figure 1. — Nuclear β-catenin in vessels of human astrocytoma does not correlate with WHO grade. (A) TCGA database analyses for Wnt1, Wnt3a, Wnt5a, Wnt7a, Wnt7b, Dkk1, and Dkk2 mRNA expression as log2-fold expression. Differences in mRNA expression in GBM compared with normal central nervous system tissue (dashed red line) are shown. (B and C) Paraffin sections of three normal human brains (B) and five different human astrocytoma WHO grades I–IV (C) stained for β-catenin and analyzed for its endothelial, nuclear localization. Insets show individual nuclei in higher magnification. Bars: (B) 14 µm; (C) 20 µm.