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. 2012 Apr 16;56(2):e15. doi: 10.4081/ejh.2012.e15

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©Copyright M. Chiusa et al., 2012

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Doxo induces myofibrillar structural damage in ARVM. Cells were cultured for 12 days and then treated with 1 µM of Doxo for 48 h. ARVM were stained for all actin using rhodamin-phalloidin (red) and immunostained for the M-line protein myomesin (green). Left: untreated ARVM. Right: structural damage was heterogeneously distributed in the cultures treated with Doxo including the presence of virtually unchanged cells (green arrow) and others losing all sarcomeric structure (red arrow). Cells from 4 hearts were independently treated and analyzed.