Figure 4.

Less effect of DHA on I_to enhanced by H₂O₂. (A) Time course of peak I_to in a myocyte treated with H₂O₂ in the absence and presence of DHA. (B) Representative traces of the I_to under control, in the presence of H₂O₂ (200 μM), and H₂O₂ + DHA (25 μM), respectively. (C) Current–voltage relations of the peak I_to (C-a) and steady state currents (I_K,SS, C-b) showing less effects of DHA on enhancement of peak I_to and I_K.ss (n = 6, *p < 0.05, **p < 0.01 vs. control.). Test potentials ranged from −60 to +50 mV in 10 mV steps. (D) Recovery of I_to from inactivation showing no significant effect of DHA (25 μM) on the I_to recovery sped-up by H₂O₂ (200 μM; p > 0.05, n = 7).