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Immunohistochemistry of thoracic (T10) spinal cord (two segments below the injury epicenter), especially areas adjacent to dorsal median septum showed huge upregulation of BDNF (B) following 1 week of bicycle locomotor training compared with contused untrained control (A). The GABA synthetic enzyme, glutamic acid decarboxylase (GAD67) showed also greater immunoreactivity (D) in the same area (1 week bicycle training) compared with untrained contused control (C; 20× magnification).
