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. 2012 Jul 9;3:259. doi: 10.3389/fphys.2012.00259

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Copyright © 2012 Camiré, Lacaille and Topolnik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Schematic representation of mGluR5 signaling in interneuron dendrites. Activation of mGluR5 may trigger phospholipase C (PLC) activation producing inositol-1,4,5-triphosphate (IP₃) and Ca²⁺ release from intracellular stores as well as diacylglycerol (DAG)/protein kinase C (PKC) activation. mGluR5-mediated Ca²⁺ release alone can be involved in LTD induction; however, together with Ca²⁺ entry through CP-AMPARs, mGluR5 appears to influence the induction of anti-Hebbian LTP. Moreover, mGluR5-dependent PKC activation produces persistent up-regulation of L-type VGCCs and may play a critical role in the regulation of Hebbian LTP.