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. 2012 Jul 17;3:281. doi: 10.3389/fphys.2012.00281

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Copyright © 2012 Baier, Goodfellow, Taylor, Wang and Garry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Illustration of qualitatively different transitions from background oscillations to pathological spike-wave and back again in a neural mass model. (A) Bifurcation: a parameter is changed such that it crosses a bifurcation point. (B) Bistability: two pulse perturbation are applied to start and terminate a seizure. (C) Excitability: a single pulse perturbation is applied to induce a seizure. (D) Intermittency: parameter setting allows spontaneous transitions into and out of the seizure rhythms. All simulations done with a three compartment version of the extended Jansen-Rit model (Goodfellow et al., 2011). Upper trace: model output. Lower trace: parameter protocol.