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Regulation of ENaC by aldosterone and vasopressin. Vasopressin release is stimulated primarily by increases in plasma osmolality but also by decreases in mean arterial pressure and is also under feedback control by the hypothalamic-pituitary-adrenal (HPA) axis as mediated by glucocorticoids. Positive and negative relations are indicated by blue and red, respectively. Weaker regulation indicated with narrower arrows.
