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. 2012 Aug 9;3:318. doi: 10.3389/fphys.2012.00318

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Copyright © 2012 Pallavi, Giorgio and Pelicci.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Caloric Restriction (CR) and Cancer. (A) CR effectively inhibits various kinds of cancer in animal models. (B) Correlation between decrease in the incidence of tumor and severity of CR. (C) Demonstration of parallel and opposing effects of CR on cancer and aging. The ability of CR to decrease the levels of IGF-1 and ROS and inhibit the PI3K-AKT pathway can simultaneously protect cells from aging and cancer. However, CR ability to maintain telomere length and reduce the frequency of senescence can promote cancer but may be also beneficial in delaying aging.