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. 2012 Aug 20;3:322. doi: 10.3389/fphys.2012.00322

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Copyright © 2012 Zahradníková and Zahradník.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Approximation of the calcium dependence of spark frequency. Open symbols with error bars represent data on permeabilized myocytes (Lukyanenko and Gyorke, 1999). The two indistinguishable lines represent the best fits by Eq. 2 with parameters shown in Tables 1, 2, and 4 for the optimal aHTG model for vCRSs composed of 1 and 10 random clusters with the size distribution shown in Figure 2. Small red and blue symbols represent spark frequency simulated using Eq. 4 for a set of 100 random vCRUs composed of 1 and 10 clusters.