Figure 7.

The dependence of RyR kinetic parameters on the cluster composition of vCRSs. (A–C) The dependence of p_A, p_dis, and $K_{\text{dis}}^{\text{Mg}}$on the number of clusters in the vCRS. Circles: vCRSs composed of a single multi-cluster vCRU. Squares: vCRSs composed of several single-cluster vCRUs. Crossed symbols: values from models with n_clust ≥ 3 and n_vCRU = 1 that match the experimental data (Figure 6). (D–F) The dependence of K_Mg, f_Mg, and p_A on $K_{\text{dis}}^{\text{Mg}}$ for vCRUs with different number of clusters.