Table 2.
Parameter | Value |
---|---|
KCa (μM) | 0.6 |
KMg (μM) | Fitted parameter |
fCa | 0.046 |
fMg | Fitted parameter |
KO0 | 10 800 |
KOL | 0.5 |
KCL | 0.89 |
KCI | 3.0 |
KI (μM) | 760 |
[Mg] (mM) | 1.0 |
KCa – calcium dissociation constant of the ion-free closed state C00.
KMg – magnesium dissociation constant of the ion-free closed state C00.
KO0 – dissociation constant of the ion-free open state O00.
fCa – allosteric factor coupling calcium binding to channel opening.
fMg – allosteric factor coupling magnesium binding to channel opening.
KOL – dissociation constant of the L-mode open state OL.
KCL – dissociation constant of the L-mode closed state CL.
KCI – dissociation constant of the inactivated state I.
KI – inhibitory constant of Mg2+ ions at the low-affinity inhibition site.
[Mg] – free Mg2+ concentration.