Table 2.

Parameters of RyR gating.

Parameter	Value
KCa (μM)	0.6
KMg (μM)	Fitted parameter
fCa	0.046
fMg	Fitted parameter
KO0	10 800
KOL	0.5
KCL	0.89
KCI	3.0
KI (μM)	760
[Mg] (mM)	1.0

K_Ca – calcium dissociation constant of the ion-free closed state C00.

K_Mg – magnesium dissociation constant of the ion-free closed state C00.

K_O0 – dissociation constant of the ion-free open state O00.

f_Ca – allosteric factor coupling calcium binding to channel opening.

f_Mg – allosteric factor coupling magnesium binding to channel opening.

K_OL – dissociation constant of the L-mode open state OL.

K_CL – dissociation constant of the L-mode closed state CL.

K_CI – dissociation constant of the inactivated state I.

K_I – inhibitory constant of Mg²⁺ ions at the low-affinity inhibition site.

[Mg] – free Mg²⁺ concentration.