Figure 4.

Decreased fasting plasma glucose concentration and hepatic glycogen content in mPer2^Brdm1 mice. (A) Decreased fasting (F) blood plasma glucose concentration in the mPer2^Brdm1 mice as compared to WT littermates at ZT9 and ZT15, which is normalized after refeeding (R). (B) Fasting hepatic glycogen content of WT and mPer2^Brdm1 mice at ZT9. (C) Representative Periodic Acid-Schiff (PAS) staining showing hepatic glycogen contents in WT and mPer2^Brdm1 mice. (D) Immunoblotting showing fasting hepatic glycogen synthase (GS) levels in WT and mPer2^Brdm1 mice. ^*p < 0.05, ^**p < 0.01, and ^***p < 0.005 between the indicated groups, respectively.