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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Cancer Res. 2012 Jun 18;72(15):3807–3816. doi: 10.1158/0008-5472.CAN-11-1063

Figure 2. MnSOD activity regulates a “metabolic switch” influencing cellular proliferation.

Figure 2

One hundred MOI of adenoviruses carrying CMV-promoter driven mouse or human MnSOD cDNA were used to infect asynchronous cultures of (A) MnSOD (−/−) MEFs and (B) MB231 cells. AdBgl II represents non-replicative adenoviral vector without MnSOD cDNA. It was included as a control for adenoviral infections (14). Glucose consumption and cell numbers were measured at 96 h post-infection for MEFs (2A), and 72 h post-infection for MB231 (2B). Asterisk indicates significant differences in glucose consumption rate and cell numbers in MnSOD overexpressing vs. control and AdBgl II infected cells; n = 3, P <0.05.