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IL-12-priming during CD8+ T cell activation leads to significantly enhanced anti-tumor activity. Mice with s.c. B16 tumors were treated on day 12 as indicated with CTX. On day 13, mice were adoptively transferred with pmelIL-12 (3×106) or pmelsham (3×106) T cells. Tumors were measured blindly twice weekly. Each line represents one mouse.
