Table 5.

Adverse Events^a in a Clinical Trial to Assess the Efficacy of S-Adenosyl-l-Methionine Versus Placebo for Smoking Abstinence

Event	Placebo (N=40)	800 mg/d (N=40)	1600 mg/d (N=40)
Abdominal pain	1 (2.5)	2 (5.0)	5 (12.5)
Nausea	2 (5.0)	2 (5.0)	2 (5.0)
Headache	2 (5.0)	2 (5.0)	0 (0.0)
Diarrhea	0 (0.0)	0 (0.0)	3 (7.5)
Insomnia	1 (2.5)	0 (0.0)	1 (2.5)
Anorexia	0 (0.0)	0 (0.0)	1 (2.5)
Confusion	0 (0.0)	0 (0.0)	1 (2.5)
Constipation	0 (0.0)	1 (2.5)	0 (0.0)
Dizziness	1 (2.5)	0 (0.0)	0 (0.0)
Drowsiness	0 (0.0)	1 (2.5)	0 (0.0)
Fatigue	0 (0.0)	1 (2.5)	0 (0.0)
Flatulence	0 (0.0)	0 (0.0)	1 (2.5)
Vivid dreams	1 (2.5)	0 (0.0)	0 (0.0)
Vomiting	0 (0.0)	0 (0.0)	1 (2.5)

^aAdverse events considered to be possibly, probably, or definitely related to study drug are summarized according to the treatment group.