Table 2.
Genotype Frequencies and Associations Between Hepatitis B Virus-Induced Disease in GNLY Single-Nucleotide Polymorphisms
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Frequency (%) |
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SR vs. CLD |
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| SNP | HWE | MAF | Genotype | SR | CLD | Model | OR | Lower CI | Upper CI | pa | pb | pc |
| rs2886767 | CC | 29 (7.27) | 73 (18.3) | Additive | 1.05 | 0.75 | 1.49 | 0.763 | ||||
| C>T | 0.523 | 0.421 | CT | 67 (16.79) | 90 (22.55) | Dominant | 0.66 | 0.39 | 1.11 | 0.117 | ||
| Flanking_5UTR | TT | 11 (2.76) | 43 (10.78) | Recessive | 2.44 | 1.19 | 5.01 | 0.015 | 0.027 | 0.074 | ||
| rs1561285 | GG | 32 (8.02) | 83 (20.8) | Additive | 0.99 | 0.68 | 1.43 | 0.951 | ||||
| G>C | 0.121 | 0.381 | CG | 70 (17.54) | 92 (23.05) | Dominant | 0.61 | 0.36 | 1.01 | 0.055 | ||
| Intron | CC | 5 (1.25) | 31 (7.77) | Recessive | 3.78 | 1.41 | 10.14 | 0.008 | 0.017 | 0.042 | ||
| rs11127 | TT | 29 (7.27) | 77 (19.3) | Additive | 1.05 | 0.74 | 1.49 | 0.790 | ||||
| T>C | 0.434 | 0.411 | CT | 70 (17.54) | 88 (22.05) | Dominant | 0.60 | 0.36 | 1.01 | 0.055 | ||
| Exon | CC | 8 (2.01) | 41 (10.28) | Recessive | 3.26 | 1.45 | 7.30 | 0.004 | 0.007 | 0.020 | ||
The CIs and pa values were obtained from logistic regression with additive, dominant, and recessive models.
The pb values were calculated by the permutation test.
The pc values were calculated by Bonferroni's correction.
SNP, single-nucleotide polymorphisms; HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.