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. Author manuscript; available in PMC: 2012 Aug 28.
Published in final edited form as: Org Lett. 2011 Feb 11;13(6):1334–1337. doi: 10.1021/ol103175w

Table 1.

Effect of Nucleophile on the Gold(I)-Catalyzed Intramolecular Amination of Allylic Alcohols 2.

graphic file with name nihms273937u2.jpg
entry R substrate time (h) pyrrolidine yield (%)a
1 Bn 2a 2 3a 97
2 n-Bu 2b 2 3b 96
3 t-Bu 2c 2 3c 87
4 H 2d 48 3d 91
5 Cbz 2e 72 3e 48
6b Cbz 2e 48 3e 97
a

Isolated yield in >95% purity.

b

AgClO4 used in place of AgSbF6