Table 4.
Cytotoxic activity of selected compounds isolated from Westiellopsis sp. (SAG 20.93) and Fischerella muscicola (UTEX LB1829)
| IC50 (μM)
|
|||||
|---|---|---|---|---|---|
| HT-29 a | MCF-7 b | NCI-H460 c | SF268 d | IMR90 e | |
| Hapalindole X (1) | 24.8 | 35.4 ± 2.8 | 23.0 ± 4.6 | 23.5 ± 9.5 | 113.2 ± 13.2 |
| 13-hydroxy dechlorofontonamide (3) | NA | >100 | >100 | >100 | >100 |
| Hapalindole I | NA | >100 | 68.5 ± 11.0 | 93.1 ± 14.0 | >100 |
| Hapalindole J | 28.6 | 43.7 ± 10.0 | 12.0 ± 1.9 | 16.9 ± 3.4 | 39.1 ± 6.6 |
| Hapalindole A | 31.3 | 30.7 ± 7.1 | 17.0 ± 4.8 | 16.3 ± 7.1 | 39.1 ± 10.2 |
| Hapalindole U | 52.6 | >100 | >100 | >100 | >100 |
| Hapalindole C | 52.6 | >100 | 53.7 ± 15.5 | 88.6 ± 17.6 | >100 |
| Hapalindole H | 10.8 | 16.3 ± 3.3 | 8.5 ± 3.7 | 10.6 ± 4.5 | 31.9 ± 11.6 |
| Anhydrohapaloxindole A | NT | 56.7 ± 10.5 | 18.7 ± 6.2 | 26.0 ± 9.0 | 80.1 ± 24.5 |
| Fischerindole L | 48.2 | 28.3 ± 8.1 | 15.1 ± 2.6 | 17.4 ± 8.6 | 46.3 ± 13.7 |
| Camptothecin | NT | 0.08 ± 0.1 | 0.002 ± 0.0 | 0.07 ± 0.1 | 0.43 ± 0.5 |
a
Human colon adenocarcinoma.
b
Human breast carcinoma.
c
Human large cell lung carcinoma.
d
Human glioblastoma cancer cell.
e
Human lung fibroblast normal cell. IC50 values were obtained by averaging the results from three independent experiments. NT represents not tested. NA represents not active.