Table 1. Demographics in “non CD” AMD, CD and control individuals.
| |
|
|
“non CD” AMD/controls |
|
CD/controls |
CD/”non CD” AMD |
|||
|---|---|---|---|---|---|---|---|---|---|
| Controls | “non CD” AMD | p-value | OR (95-C.I.) | CD | p-value | OR (95-C.I.) | p-value | OR (95-C.I.) | |
| N |
553 |
540 |
217 |
|
|
|
|
||
| Mean age (SD) |
73.1 (6.25) |
76.7 (7.42) |
|
|
69.3 (10.40) |
|
|
|
|
|
Gender | |||||||||
| Male (%) |
242 (43.8%) |
210 (38.9%) |
0.040* |
1.33 (1.01–1.75)* |
77 (35.5%) |
0.086* |
1.36 (0.96–1.92)* |
0.232* |
1.27 (0.86–1.88)* |
| Female (%) |
311 (56.2%) |
330 (61.1%) |
|
|
140 (64.5%) |
|
|
|
|
|
BMI | |||||||||
| <25 (%) |
242 (43.8%) |
224 (41.5%) |
Ref. |
|
95 (43.8%) |
Ref. |
|
Ref. |
|
| 25–30 (%) |
249 (45.0%) |
235 (43.5%) |
0.169† |
1.21 (0.92–1.59)† |
92 (42.4%) |
0.616† |
0.92 (0.65–1.30)† |
0.079† |
0.71 (0.49–1.04)† |
| >30 (%) |
62 (11.2%) |
81 (15.0%) |
0.027† |
1.58 (1.05–2.36)† |
30 (13.8%) |
0.635† |
1.13 (0.68–1.89)† |
0.079† |
0.62 (0.36–1.06)† |
|
Smoking status | |||||||||
| Never (%) |
257 (46.5%) |
230 (42.6%) |
Ref. |
|
99 (45.6%) |
Ref. |
|
Ref. |
|
| Past (%) |
272 (49.2%) |
230 (42.6%) |
0.685‡ |
1.06 (0.80–1.40)‡ |
96 (44.2%) |
0.977‡ |
1.01 (0.71–1.43)‡ |
0.845‡ |
0.96 (0.64–1.44) ‡ |
| Current (%) | 24 (4.3%) | 80 (14.8%) | 2.4x10–11‡ | 5.97 (3.54–10.09)‡ | 22 (10.1%) | 0.032‡ | 2.06 (1.07–4.00)‡ | 2.1x10–4‡ | 0.32 (0.17–0.58) ‡ |
Abbreviations: AMD=age-related macular degeneration; CD=cuticular drusen; OR=odds ratio; CI=confidence interval; BMI=body-mass index; Ref.=reference group. * Adjusted for age, body-mass index and smoking status. † Adjusted for age, gender and smoking status. ‡ Adjusted for age, gender and body-mass index. p-values and ORs printed in boldface indicate significant associations.