Table 2. Risk allele frequencies in “non CD” AMD, CD and control individuals.
| |
|
|
“non CD” AMD/controls |
|
CD/controls |
CD/”non CD” AMD |
|||
|---|---|---|---|---|---|---|---|---|---|
| Controls (%) | “non CD” AMD (%) | p-value | OR (95-C.I.) | CD (%) | p-value | OR (95-C.I.) | p-value | OR (95-C.I.) | |
|
rs10490924/ ARMS2 A69S |
21.9 |
42.9 |
2.0×10−21 |
2.94 (2.35–3.67) |
38.3 |
1.7×10−9 |
2.25 (1.73–2.93) |
0.140 |
0.83 (0.64–1.06) |
|
rs1061170/ CFH Y402H |
38.1 |
57.7 |
1.9×10−14 |
2.17 (1.78–2.65) |
64.1 |
8.6×10−16 |
2.88 (2.23–3.73) |
0.022 |
1.35 (1.04–1.74) |
|
rs1410996/ CFH |
56.9 |
74.8 |
9.7×10−15 |
2.25 (1.83–2.76) |
76.8 |
3.0×10−11 |
2.53 (1.93–3.33) |
0.209 |
1.20 (0.90–1.61) |
|
rs9332739/ C2 E318D |
4.7 |
2.5 |
0.004 |
0.47 (0.28–0.79) |
1.9 |
0.016 |
0.38 (0.17–0.83) |
0.744 |
0.86 (0.34–2.15) |
|
rs2230199/ C3 R102G |
20.8 |
27.4 |
0.001 |
1.46 (1.18–1.80) |
27.9 |
0.013 |
1.42 (1.08–1.88) |
0.965 |
1.01 (0.77–1.32) |
|
rs4151667/ CFB H9L |
4.9 |
2.8 |
0.006 |
0.49 (0.29–0.82) |
2.3 |
0.027 |
0.42 (0.19–0.91) |
0.750 |
0.86 (0.35–2.14) |
|
rs10033900/ CFI |
48.2 |
51.8 |
0.101 |
1.17 (0.97–1.42) |
51.5 |
0.232 |
1.16 (0.91–1.49) |
0.809 |
1.03 (0.79–1.35) |
|
rs7412/ APOE2 |
8.0 |
10.7 |
0.115 |
1.29 (0.94–1.77) |
12.1 |
0.011 |
1.65 (1.12–2.42) |
0.131 |
1.37 (0.91–2.05) |
| rs429358/ APOE4 | 14.4 | 10.2 | 0.058 | 0.74 (0.54–1.01) | 11.1 | 0.047 | 0.68 (0.46–1.00) | 0.660 | 0.91 (0.59–1.40) |
Abbreviations: AMD=age-related macular degeneration; CD=cuticular drusen; OR=odds ratio; CI=confidence interval; ARMS2=age-related maculopathy susceptibility 2; CFH=complement factor H; C2=complement component 2; C3=complement component 3; CFB=complement factor B; CFI=complement factor I; APOE=apolipoprotein E. Missings in genotypes are <15%. Data are adjusted for age, gender, body-mass index and smoking status. Risk allele frequencies of rs10490924, rs1061170, rs1410996, rs9332739, rs2230199, and rs4151667 are significantly associated with “non CD” AMD compared to controls. Risk allele frequencies of rs10490924, rs1061170, rs1410996, rs9332739, rs2230199, rs4151667, rs7412, and rs429358 are significantly associated with CD compared to controls. The risk allele frequency of rs1061170 is significantly higher in CD compared to “non CD” AMD.