. 2012 Aug 28;9(8):e1001300. doi: 10.1371/journal.pmed.1001300

Table 3. Association of number of likely effective drugs with treatment success—during different phases of treatment.

n Likely Effective Drugs – All Patients – Three Analyses	All Patients – Success Versus Fail/Relapse		All Patients – Success Versus Fail/Relapse/Death		All Patients – Success Versus Fail/Relapse/Death/Default
	n	aOR (95% CI)	n	aOR (95% CI)	n	aOR (95% CI)
Initial intensive phase
0–2	118	1.0 (reference)	277	1.0 (reference)	322	1.0 (reference)
3	161	1.1 (0.5–2.4)^a	250	1.7 (1.2–2.5)^a	316	1.2 (0.8–1.8)^a
4	468	2.0 (1.1–3.6) ^a	542	2.7 (1.9–3.9) ^a	671	1.9 (1.3–2.9) ^a
5	814	2.0 (1.1–3.6) ^a	900	2.8 (1.7–4.6) ^a	1,114	1.9 (1.2–3.0) ^a
6+	811	2.4 (1.0–5.4) ^a	977	2.1 (1.4–3.1) ^a	1,185	1.4 (1.0–2.1) ^a
Continuation phase
0–2	254	1.0 (reference)	531	1.0 (reference)	633	1.0 (reference)
3	552	2.5 (1.6–4.0) ^b	635	5.7 (3.4–9.7) ^a	759	4.9 (2.7–8.7) ^a
4	598	2.8 (1.6–4.9) ^a	663	5.7 (3.2–10.0) ^a	779	4.2 (2.6–6.7) ^a
5+	560	2.0 (0.9–4.2) ^a	608	7.0 (5.1–9.7) ^b	656	4.9 (2.5–9.5) ^a

Likely effective, drugs to which isolate susceptible in laboratory testing. n, number of patients in subgroup of interest. aOR, adjusted for age, sex, HIV, past TB treatment, past MDR treatment (treatment for more than 1 mo with two or more second-line drugs), and extent of disease. Missing information was imputed for the following parameters in the following number of patients: Sex was missing in three, age was missing in 27, HIV was missing in 1,271(14%), history of past TB treatment missing in 443 (5%), history of past second-line drug use 758 (8%), and extent of disease information missing in 174 (2%). Success, defined as cure or treatment completion; see Methods for definitions. Initial intensive phase, period when injectable given. Continuation phase, period when no injectable given. Only 18 studies provided information regarding drug susceptibility testing and the number of drugs in the initial phase, while only 15 of these described the number of drugs in the continuation phase. Bold, estimates are significantly different from the reference group.

Variance of the random intercepts and slopes was low—so heterogeneity not likely to be important.

Variance of the random intercepts and slopes could not be estimated.