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. 2012 Aug 28;7(8):e43965. doi: 10.1371/journal.pone.0043965

Figure 11. Comparison of AKR1C1, 1C2, and 1C3 active sites and indomethacin or sulindac binding modes.

Figure 11

A. The indomethancin, pH 6.0 binding mode in AKR1C3 (black) and AKR1C1/2 (white) active sites. Clashes between the inhibitor and AKR1C1/2 are indicated. B. The indomethancin, pH 7.5 binding mode in AKR1C3 (black) and AKR1C1/2 (white) active sites. Clashes between the inhibitor and AKR1C1/2 are indicated. C. The zomepirac binding mode in AKR1C3 (black) and AKR1C1/2 (white) active sites. Clashes between the inhibitor and AKR1C1/2 are indicated. D. Sulindac binding in AKR1C3 (black) and AKR1C1/2 (white) active sites. In each figure the numbering corresponds to the AKR1C2 amino acid sequence.