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. 2012 Aug 28;7(8):e43282. doi: 10.1371/journal.pone.0043282

Figure 6. Severely down-regulated cardiac function and cardiac fibrosis in HRC-KD heart under heart failure condition.

Figure 6

A: Representative M-mode echocardiograms of all groups. Echocardiography on the experimental animals was performed at 1, 5, 9, and 11 weeks after sham or TAC operation. B: Changes in fractional shortening after viral injection for the duration of 11 weeks in sham- and TAC-operated shNC and shHRC mice. HRC-KD heart showed most severely down-regulated fractional shortening (FS) under heart failure condition. C: Masson’s trichrome staining results. Blue color indicates the appearance of collagen; red color indicates that the cytoplasmic area is occupied by myocytes and erythrocytes; black color indicates the presence of nuclei. HRC-KD heart showed most severe fibrosis under heart failure condition. shNC, negative control of AAV9; shHRC, HRC-KD through AAV9 (*P<0.05).