Table 1. Echocardiographic data associated with HRC-KD in TAC-HF model.

	shNC		shHRC
	Sham (n = 4)	Failure (n = 7)	Sham (n = 4)	Failure (n = 7)
SWTd (mm)	0.875±0.05	0.971±0.125	0.85±0.058	0.85±0.238
LVEDD (mm)	3.475±0.287	4.0±0.208*	3.3±0.283	4.45±0.311##,†
PWTd (mm)	0.9±0.141	0.986±0.09	0.95±0.058	0.8±0.082#,†
SWTs (mm)	1.725±0.222	1.486±0.146*	1.65±0.252	1.325±0.096#,†
LVESD (mm)	1.4±0.216	2.871±0.386**	1.3±0.183	3.225±0.457##,†
PWTs (mm)	1.825±0.206	1.486±0.168*	1.725±0.206	1.25±0.1##,†
FS (%)	59.5±4.359	31.0±2.757**	57.75±4.5	25.25±3.304##,†

Parameters of echocardiography obtained from shNC and shHRC mice at 11 weeks after sham or TAC operation. The most severe cardiac dilation and fractional shortening (FS) were observed in shHRC failure mice. shNC, negative control hearts through AAV9; shHRC, HRC-KD hearts through AAV9. SWTd, diastolic septal wall thickness; SWTs, septal wall thickness; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; PWTd, diastolic posterior wall thickness; PWTs, systolic posterior wall thickness; FS, fractional shortening.

^*, P<0.05;

^**, P<0.01 versus shNC sham;

^#, P<0.05;

^##, P<0.01 versus shHRC sham;

^†, P<0.05;

^††, P<0.01 versus shNC failure.