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. 2012 Aug 28;7(8):e41731. doi: 10.1371/journal.pone.0041731

Figure 5. Modeled solution structure of the cross-linked complex between AG22 (1–422) S16D/S411D and 14-3-3.

Figure 5

The model of the cross-linked complex is shown with the 14-3-3 dimer in grey, the AG22 PH domain (residues 1–145) in orange and the AG22 linker and RhoGAP domain (146–372) in red. For clarity, the C-terminal residues 373–422 of AG22 are not shown. The intermolecular cross-links between AG22 (1–422) S16D/S411D and 14-3-3 are indicated with dark blue lines: these are K15AG:K7014-3-3, K45AG:K7014-3-3, K45AG:K7714-3-3 and K52AG:K12214-3-3. The cross-linked lysine sidechains are shown in magenta. The figure was generated using PyMol [33].