Figure 3. Combined STAT3 and p38 MAPK inhibition consistently prevents suppression of human MoDC differentiation by supernatants from a panel of tumor cell lines. Eleven supernatants derived from the indicated tumor cell lines representing 8 different tumor types were added during differentiation. The percentages of CD1a⁺ and CD14⁺ cells after normal DC differentiation with GM-CSF and IL-4 are indicated by the dotted lines. Shown are mean ± SD from 3 experiments. * = p < 0,05 compared with differentiation without inhibitors.