Table 1. The number of FUS-regulated exons with proximal crosslink clusters of FUS, TDP-43 or U2AF65. The exons with lower (, dIrank<−1.5) or higher (, dIrank>1.5) inclusion in WT than FUS−/− brain are evaluated, and compared to control exons (all alternative exons detected by microarray). The last column shows the total number of these exons, and the first three columns show the number of these exons that contain FUS, TDP-43 or U2AF65 crosslink cluster within 250nt from the middle of the exon. Crosslink clusters were determined using flank = 200 and FDR<0.05. The star indicates that the proportion of exons repressed by FUS with a FUS crosslink cluster (5/20) is significantly increased compared to control exons with a FUS crosslink cluster (177/5779) (p-value = 0.0003, Fisher's exact test).

	FUS	TDP-43	U2	total
	5*	2	8	20
	0	1	2	6
control	177	273	1098	5779