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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: J Neurosci Methods. 2012 Jul 4;209(2):337–343. doi: 10.1016/j.jneumeth.2012.06.029

Fig. 4.

Fig. 4

Mean effect of 10% carbon dioxide and 4 mg/kg morphine on breathing frequency and tidal volume. Administration of carbon dioxide produced an increase in rate and tidal volume detected by all three methods. Morphine produced a decrease in breathing frequency and tidal volume evident with all three methods, but ACC significantly overestimated the effect of morphine on tidal volume. *p < 0.05, **p < 0.01, and ***p < 0.001 compared to pre-treatment; #p < 0.05 compared to WBP.