(A-C) Mouse/human alignment of consensus NFI-binding sites and schematic of MBP, PLP, and MAG promoters. (D-F) ChIP assay from E12.5 mouse spinal cord; arrows denote ChIP primers encompassing conserved NFI-site (red oval). (G-I) Reporter assays demonstrating NFIA repression of MBP, PLP, and MAG promoter activity. In G-I, *p<.01. All error bars indicate SD.