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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Ann Neurol. 2012 Jul 17;72(2):224–233. doi: 10.1002/ana.23590

Figure 5. NFIA associates with myelin gene promoters and represses their activity.

Figure 5

(A-C) Mouse/human alignment of consensus NFI-binding sites and schematic of MBP, PLP, and MAG promoters. (D-F) ChIP assay from E12.5 mouse spinal cord; arrows denote ChIP primers encompassing conserved NFI-site (red oval). (G-I) Reporter assays demonstrating NFIA repression of MBP, PLP, and MAG promoter activity. In G-I, *p<.01. All error bars indicate SD.