Table V.
First Series of Assessments: Deposition Profile Data (microgram per actuation) from DPI Inhaler “A” for the NGI at Different Sample Durations
| Duration | 1 s | 2 s | 4 s | 8 s | 16 s | Controla | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Location | Mean | CofV | Mean | CofV | Mean | CofV | Mean | CofV | Mean | CofV | |
| I.P. | 219.5 | 9.8 | 213.8 | 7.4 | 227.0 | 4.2 | 225.7 | 4.0 | 216.3 | 2.3 | 166.5 |
| P.S. | 331.5 | 10.5 | 285.5 | 5.8 | 293.1 | 6.2 | 265.3 | 16.1 | 324.3 | 2.5 | 325.8 |
| Stage 1 | 41.3 | 10.4 | 32.4 | 7.1 | 30.4 | 10.0 | 30.2 | 16.4 | 32.8 | 3.6 | 36.0 |
| Stage 2 | 50.4 | 10.7 | 68.3 | 10.5 | 75.2 | 1.4 | 74.4 | 13.3 | 77.2 | 1.1 | 79.4 |
| Stage 3 | 39.4 | 12.2 | 65.6 | 8.9 | 77.3 | 9.3 | 72.7 | 5.5 | 67.0 | 3.4 | 71.0 |
| Stage 4 | 22.7 | 3.8 | 43.7 | 14.2 | 45.0 | 28.6 | 53.5 | 8.4 | 42.4 | 3.1 | 49.6 |
| Stage 5 | 4.2 | 25.1 | 10.8 | 20.4 | 12.4 | 11.0 | 13.5 | 16.7 | 13.1 | 15.3 | 14.2 |
| Stage 6 | 0.7 | 17.3 | 2.1 | 19.5 | 2.3 | 19.3 | 2.8 | 40.0 | 2.5 | 14.4 | 3.3 |
| Stage 7 | 0.0 | 173.2 | 0.5 | 12.4 | 0.4 | 25.0 | 0.4 | 25.0 | 0.5 | 20.0 | 0.6 |
| Filter | 0.0 | – | 0.1 | 0.0 | 0.1 | 43.3 | 0.1 | 0.0 | 0.1 | 43.3 | 0.2 |
IP GSK Induction Port, PS NGI preseparator, CofV coefficient of variation (%)
aSingle measurement for control