Table II.
Parameters | Tissues | C-Inj | C-Lip | F-Lip |
---|---|---|---|---|
AUC (ng/h/g) | Plasma | 1,035.1 | 13,357.3 | 12,952.0 |
Liver | 9,670.1 | 18,834.9 | 21,056.2 | |
Rectum | 6,486.4 | 6,784.6 | 10,370.7 | |
Tumor | 1,249.4 | 1,537.7 | 2,506.2 | |
C max (ng/g) | Plasma | / | / | / |
Liver | 3,988.5 ± 808.5 | 5,612.0 ± 145.7* | 6,079 ± 528.8* | |
Rectum | 1,455.1 ± 367.2 | 1,191.9 ± 46.6 | 2,108.0 ± 306.6**,*** | |
Tumor | 610.6 ± 28.0 | 710.1 ± 27.6* | 774.9 ± 46.0** |
Results of C max are given as mean ± SD, and the others are given as mean (n = 5). AUC values are calculated for 0–8 h. AUC value in plasma is given as nanogram hour per milliliter
AUC area under the curve, C-Inj CPT-11 injection, C-Lip CPT-11-loaded liposome, F-Lip CPT-11-loaded folate-targeted liposome
*p < 0.05 vs control group (C-Inj); **p < 0.01 vs control group (C-Inj); ***p < 0.01 vs C-Lip group