Table III.
Pharmacokinetic Parameters of SN-38 in the Plasma and Tissues After i.v. Administration of C-Inj, C-Lip, and F-Lip, Respectively
| Parameters | Tissues | C-Inj | C-Lip | F-Lip |
|---|---|---|---|---|
| AUC (ng/h/g) | Plasma | 192.2 | 225.8 | 276.7 |
| Liver | 327.3 | 659.2 | 844.2 | |
| Rectum | 159.0 | 172.1 | 334.2 | |
| Tumor | 374.3 | 462.4 | 449.4 | |
| C max (ng/g) | Plasma | 61.8 ± 8.6 | 66.1 ± 7.0 | 95.6 ± 16.2*,*** |
| Liver | 61.1 ± 12.4 | 338.7 ± 198.1* | 223.5 ± 36.5** | |
| Rectum | 26.9 ± 6.4 | 39.3 ± 12.8 | 53.3 ± 10.4* | |
| Tumor | 125.2 ± 11.1 | 187.3 ± 5.5** | 316.3 ± 10.5**,**** |
Results of C max are given as mean ± SD, and the others are given as mean (n = 5). AUC values are calculated for 0–8 h. AUC value in plasma is given as nanogram hour per milliliter
AUC area under the curve, C-Inj CPT-11 injection, C-Lip CPT-11-loaded liposome, F-Lip CPT-11-loaded folate-targeted liposome
*p < 0.05 vs control group (C-Inj); **p < 0.01 vs control group (C-Inj); ***p < 0.05 vs C-Lip group; ****p < 0.01 vs C-Lip group