Table I.
Formulations Composition and Processing Parameters for Preparing MN Tablets
| Parameter | Formula code | |||
|---|---|---|---|---|
| F1 | F2 | F3 | F4 | |
| Lubricant type | Sodium lauryl sulfate | Sodium lauryl sulfate | Magnesium stearate | Magnesium stearate |
| Disintegrant type | Croscarmellose sodium | Explotab low pH | Plasdone XL100 | Croscarmellose sodium |
| Intragranular disintegrant (g) | 4.8 | 10.8 | 9.0 | 14.4 |
| Disintegrant (%) | 6 | 9 | 9 | 12 |
| Glidant type | Aerosil 300 | Aerosil 300 | Aerosil R972 | Aerosil 380 |
| Urea (g) | 18 | 24 | 6 | 6 |
| Mannitol (g) | 58 | 78 | 81 | 58 |
| Microcrystalline cellulose (g) | 58 | 26 | 41 | 58 |
| Impeller speed (rpm) | 100 | 80 | 100 | 80 |
| Milling parameters | ||||
| (a) Sieve diameter (μm) | 1,000 | 1,000 | 500 | 500 |
| (b) Speed (rpm) | 1,000 | 2,000 | 1,000 | 2,000 |
| Volume of water (ml) | 59.8 | 57.7 | 63.4 | 63.1 |
| Tablet hardness (N) | 25 | 25 | 25 | 35 |