Table 1.
Variables by responder group CR vs. ICR (Mann Whitney U test). Four factors were significantly different between groups: BE length, hiatal hernia length, WAR, and TR. While there was a trend for WAlkR, it was not statistically significant.
| Variable | CR (N = 22) | ICR (N =15 ) | Test Statistic | ||||
|---|---|---|---|---|---|---|---|
| Median | Variance | Median | Variance | z | p | 95% CI | |
| Baseline Characteristics | |||||||
| Age | 63.0 | 147 | 68.0 | 101 | 1.5 | 0.14 | |
| BE (cm) | 4.0 | 3.9 | 6.0 | 10.4 | 3.1 | <.01 | −5.0,0.1 |
| Histology NDBE/LGD/HGD | 7/10/5 | 4/7/4 | X2 = 0.14, p =0 .93 | ||||
| HH (cm) | 2.3 | 1.5 | 3.0 | 9.2 | 3.2 | <.01 | −3,−0.5 |
| BMI | 28.0 | 16.0 | 30.0 | 21.1 | 1.3 | 0.19 | |
| Never Smoked | 15 (68%) | 12 (80%) | X2 = 1.0, p = 0.59 | ||||
| High Resolution Manometry | |||||||
| EGJP (mmHg) | 7.5 | 62.8 | 6.0 | 28.9 | −0.82 | 0.42 | |
| DCI (mmHg-s-cm) | 648 | 1501343 | 566 | 732623 | −0.43 | 0.68 | |
| Peristalsis Weak/ Absent (%) | 35.0 | 1140 | 30.0 | 1174 | −0.03 | 0.99 | |
| Peristalsis present (%) | 50.0 | 1023 | 60.0 | 1167 | 0.05 | 0.53 | |
| pH-Impedance Monitoring | |||||||
| Acid exposure time (%) | 0.20 | 26.6 | 0.20 | 119 | 0.26 | 0.57 | |
| AR | 2.0 | 360 | 3.0 | 1076 | 0.48 | 0.64 | |
| WAlkR | 1.0 | 25.4 | 5.0 | 82.1 | 1.9 | 0.06 | −8.0,0 |
| WAR | 29.5 | 695 | 52.0 | 2762 | 2.2 | 0.03 | −65.0,− 2.0 |
| TR | 33.5 | 999 | 60.0 | 2779 | 2.1 | 0.03 | −67.0,−4.0 |
Abbreviations: CR, complete response; ICR, incomplete response; BE, Barrett’s Esophagus; NDBE, non-dysplastic Barrett’s esophagus; LGD, low grade dysplasia; HGD, high grade dysplasia; HH, hiatal hernia; BMI, body mass index, EGJP, esophagogastric junction pressure; DCI, distal contractile integral; AR, acid reflux; WAlkR, weakly alkaline reflux; WAR, weakly acidic reflux; TR, total reflux